{"id":23070,"date":"2017-04-15T13:02:41","date_gmt":"2017-04-15T08:32:41","guid":{"rendered":"http:\/\/agna.ir\/?p=23070"},"modified":"2017-04-15T13:05:17","modified_gmt":"2017-04-15T08:35:17","slug":"%d9%85%d8%b2%d8%a7%db%8c%d8%a7%db%8c-%d8%aa%d8%ba%d8%b0%db%8c%d9%87-%d9%85%d8%aa%db%8c%d9%88%d9%86%db%8c%d9%86-%d8%af%d8%b1-%d8%b7%d9%88%d9%84-%d8%af%d9%88%d8%b1%d9%87-%d8%a7%d9%86%d8%aa%d9%82%d8%a7","status":"publish","type":"post","link":"https:\/\/agna.ir\/?p=23070","title":{"rendered":"\u0645\u0632\u0627\u06cc\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644"},"content":{"rendered":"

\u0645\u0632\u0627\u06cc\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644:
\nThe Benefits of Feeding Methionine during the Transition Phase:
\nD. Luchini and J. Loor
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\n\u0645\u062f\u06cc\u0631\u06cc\u062a \u062a\u063a\u0630\u06cc\u0647 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u062a\u0627\u062b\u06cc\u0631\u0627\u062a\u06cc \u0628\u0631 \u0639\u0645\u0644\u06a9\u0631\u062f \u0627\u06cc\u0645\u0646\u06cc \u0648 \u0633\u0644\u0627\u0645\u062a \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u06a9 \u062d\u06cc\u0648\u0627\u0646 \u0628\u06af\u0630\u0627\u0631\u062f (Waldron, 2014). \u062f\u0631 \u0637\u0648\u0644 \u0627\u06cc\u0646 \u062f\u0648\u0631\u0647 \u062a\u0639\u0627\u062f\u0644 \u0645\u0646\u0641\u06cc \u0645\u0648\u0627\u062f \u0645\u063a\u0630\u06cc\u060c \u06af\u0627\u0648\u0647\u0627 \u0630\u062e\u0627\u06cc\u0631 \u0628\u062f\u0646\u06cc \u0634\u0627\u0645\u0644 \u0686\u0631\u0628\u06cc\u060c \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0648 \u06af\u0644\u06cc\u06a9\u0648\u0698\u0646 \u0631\u0627 \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0627\u06a9\u0633\u06cc\u062f\u0627\u0633\u06cc\u0648\u0646 \u0648 \u06af\u0644\u0648\u06a9\u0648\u0646\u0626\u0648\u0698\u0646\u0632 \u06a9\u0628\u062f\u06cc \u0628\u0631\u0627\u06cc \u062a\u0648\u0644\u06cc\u062f \u0634\u06cc\u0631 \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0642\u0631\u0627\u0631 \u0645\u06cc \u062f\u0647\u0646\u062f. \u0628\u0627 \u0648\u062c\u0648\u062f \u062a\u0648\u062c\u0647 \u0632\u06cc\u0627\u062f\u06cc \u06a9\u0647 \u0628\u0647 \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0642\u0631\u0627\u0631 \u062f\u0627\u062f\u0646 \u0627\u0633\u06cc\u062f\u0647\u0627\u06cc \u0686\u0631\u0628 \u0648 \u0627\u062b\u0631\u0627\u062a \u0622\u0646 \u0628\u0631 \u0633\u0644\u0627\u0645\u062a \u06a9\u0628\u062f \u0634\u062f\u0647\u060c \u0645\u0647\u0645 \u0627\u0633\u062a \u0628\u062f\u0627\u0646\u06cc\u0645 \u06a9\u0647 \u06af\u0627\u0648\u0647\u0627 \u062a\u0627 \u06f4\u06f4 \u067e\u0648\u0646\u062f (\u06f2\u06f0 \u06a9\u06cc\u0644\u0648\u06af\u0631\u0645) \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0631\u0627 \u062f\u0631 \u0627\u0648\u0627\u06cc\u0644 \u062f\u0648\u0631\u0647 \u0634\u06cc\u0631\u062f\u0647\u06cc \u0627\u0632 \u062f\u0633\u062a \u0645\u06cc \u062f\u0647\u0646\u062f (Khula et al, 2011).
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\u06cc\u0627\u0628\u062f. \u062f\u0631 \u062d\u0627\u0644\u06cc \u06a9\u0647 \u0627\u062a\u0644\u0627\u0641 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0648 \u0627\u0633\u06cc\u062f\u0647\u0627\u06cc \u0622\u0645\u06cc\u0646\u0647 \u062f\u0631 \u0637\u0648\u0644 \u0647\u0641\u062a\u0647 \u0647\u0627\u06cc \u0627\u0628\u062a\u062f\u0627\u06cc\u06cc \u062f\u0648\u0631\u0647 \u0634\u06cc\u0631\u062f\u0647\u06cc \u0627\u062f\u0627\u0645\u0647 \u0645\u06cc \u06cc\u0627\u0628\u062f\u060c \u06af\u0644\u06cc\u06a9\u0648\u0698\u0646 \u0645\u0627\u0647\u06cc\u0686\u0647 \u0648 \u0630\u062e\u0627\u06cc\u0631 \u0686\u0631\u0628\u06cc \u0628\u0644\u0627\u0641\u0627\u0635\u0644\u0647 \u0628\u0639\u062f \u0627\u0632 \u0632\u0627\u06cc\u0645\u0627\u0646 \u062f\u0686\u0627\u0631 \u06a9\u0627\u0647\u0634 \u0645\u06cc \u0634\u0648\u0646\u062f (\u0634\u06a9\u0644 \u06f1).
\n\u0634\u06a9\u0644 \u06f1: \u06af\u0644\u06cc\u06a9\u0648\u0698\u0646 \u0645\u0627\u0647\u06cc\u0686\u0647\u060c \u0686\u0631\u0628\u06cc \u0648 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u06af\u0627\u0648 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u067e\u06cc\u0634 \u0627\u0632 \u0632\u0627\u06cc\u0634<\/p>\n

\u0645\u06a9 \u06a9\u0627\u0631\u062a\u06cc \u0648 \u0647\u0645\u06a9\u0627\u0631\u0627\u0646 (\u06f1\u06f9\u06f6\u06f8) \u0628\u06cc\u0627\u0646 \u06a9\u0631\u062f\u0646\u062f \u06a9\u0647 \u06a9\u0645\u0628\u0648\u062f \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0646\u0634\u062e\u0648\u0627\u0631\u06a9\u0646\u0646\u062f\u06af\u0627\u0646 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0628\u0627\u0639\u062b \u0645\u062d\u062f\u0648\u062f \u0634\u062f\u0646 \u0633\u0646\u062a\u0632 VLDL \u062f\u0631 \u06a9\u0628\u062f \u0648 \u062f\u0631 \u0646\u062a\u06cc\u062c\u0647 \u0645\u0646\u062c\u0631 \u0628\u0647 \u06a9\u062a\u0648\u0632 \u0634\u0648\u062f. \u0645\u06cc\u0632\u0627\u0646 \u0633\u0646\u062a\u0632 VLDL \u062f\u0631 \u06a9\u0628\u062f \u0646\u0634\u062e\u0648\u0627\u0631\u06a9\u0646\u0646\u062f\u06af\u0627\u0646 \u0646\u0633\u0628\u062a \u0628\u0647 \u062a\u06a9 \u0645\u0639\u062f\u0647 \u0627\u06cc \u0647\u0627 \u06a9\u0645\u062a\u0631 \u0627\u0633\u062a (Pullen et al.,1990). \u0627\u06cc\u0646 \u0648\u06cc\u0698\u06af\u06cc \u0630\u0627\u062a\u06cc \u0646\u0634\u062e\u0648\u0627\u0631\u06a9\u0646\u0646\u062f\u06af\u0627\u0646 \u0628\u0647 \u062e\u0635\u0648\u0635 \u062f\u0631 \u0632\u0645\u0627\u0646 \u0632\u0627\u06cc\u0645\u0627\u0646 \u06a9\u0647 \u0633\u0627\u0632\u06af\u0627\u0631\u06cc \u0628\u062f\u0646 \u0628\u0627 \u0634\u0631\u0627\u06cc\u0637 \u062c\u062f\u06cc\u062f \u067e\u0633 \u0627\u0632 \u0632\u0627\u06cc\u0634 \u0645\u0646\u062c\u0631 \u0628\u0647 \u0627\u0641\u0632\u0627\u06cc\u0634 \u0645\u062d\u0633\u0648\u0633 NEFA \u062f\u0631 \u06a9\u0628\u062f \u0645\u06cc \u0634\u0648\u062f\u060c \u0627\u0647\u0645\u06cc\u062a \u067e\u06cc\u062f\u0627 \u0645\u06cc \u06a9\u0646\u062f. \u0627\u0632 \u0627\u06cc\u0646 \u0631\u0648\u060c \u0627\u0645\u06a9\u0627\u0646 \u0644\u06cc\u067e\u06cc\u062f\u0648\u0632\u06cc\u0633 (\u0627\u062e\u062a\u0644\u0627\u0644 \u062f\u0631 \u0633\u0648\u062e\u062a \u0648 \u0633\u0627\u0632 \u0686\u0631\u0628\u06cc) \u06a9\u0628\u062f\u06cc \u0627\u0641\u0632\u0627\u06cc\u0634 \u0645\u06cc \u06cc\u0627\u0628\u062f (Grummer, 1993).
\n\u06af\u0631\u0627\u0645\u0631 \u0627\u06cc\u0646 \u0645\u0648\u0636\u0648\u0639 \u0631\u0627 \u0645\u0637\u0631\u062d \u06a9\u0631\u062f \u06a9\u0647 \u0645\u0635\u0631\u0641 \u062a\u0631\u06cc \u0627\u0633\u06cc\u0644 \u06af\u0644\u06cc\u0633\u0631\u0648\u0644 (TAG) \u0628\u0631\u0627\u06cc \u0633\u0646\u062a\u0632 VLDL \u067e\u0633 \u0627\u0632 \u0632\u0627\u06cc\u0634 \u062f\u0631 \u0632\u0645\u0627\u0646\u06cc \u06a9\u0647 \u0633\u0637\u062d \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u06a9\u0628\u062f\u06cc \u0646\u0627\u06a9\u0627\u0641\u06cc \u0627\u0633\u062a \u062f\u0686\u0627\u0631 \u0627\u062e\u062a\u0644\u0627\u0644 \u0645\u06cc \u0634\u0648\u062f. \u062a\u063a\u0630\u06cc\u0647 \u0628\u0627 \u06cc\u06a9 \u062c\u06cc\u0631\u0647 \u063a\u0646\u06cc \u0634\u062f\u0647 \u0628\u0627 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0633\u0646\u062a\u0632 \u0622\u067e\u0648\u067e\u0631\u0648\u062a\u0626\u06cc\u0646 B \u0648 \u0641\u0633\u0641\u0627\u062a\u06cc\u062f\u06cc\u0644 \u06a9\u0648\u0644\u06cc\u0646 \u0627\u0647\u0645\u06cc\u062a \u062f\u0627\u0631\u062f \u0686\u0631\u0627\u06a9\u0647 \u0647\u0631\u062f\u0648\u06cc \u0627\u06cc\u0646 \u0647\u0627 \u0628\u0631\u0627\u06cc \u062a\u0634\u06a9\u06cc\u0644 VLDL \u0648 \u062d\u0635\u0648\u0644 \u0627\u0637\u0645\u06cc\u0646\u0627\u0646 \u0627\u0632 \u0627\u0646\u062a\u0642\u0627\u0644 \u0648 \u062e\u0631\u0648\u062c \u0686\u0631\u0628\u06cc \u0647\u0627 \u0627\u0632 \u06a9\u0628\u062f \u0636\u0631\u0648\u0631\u06cc \u0647\u0633\u062a\u0646\u062f(Durand, 1992) . \u0628\u0633\u06cc\u0627\u0631\u06cc \u0627\u0632 \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u0627\u0646\u062c\u0627\u0645 \u0634\u062f\u0647 \u0627\u062e\u06cc\u0631 \u0628\u0647 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u06cc\u0646 \u0633\u0637\u0648\u062d \u067e\u0627\u06cc\u06cc\u0646 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u0633\u0631\u0645 \u062e\u0648\u0646 \u0648 \u0644\u06cc\u067e\u06cc\u062f\u0648\u0632\u06cc\u0633 \u0634\u062f\u06cc\u062f \u06a9\u0628\u062f\u06cc \u062f\u0631 \u0637\u0648\u0644 \u06f1\u06f4 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u0632\u0627\u06cc\u0634 \u0627\u0634\u0627\u0631\u0647 \u06a9\u0631\u062f\u0647 \u0627\u0646\u062f (Shibano and Kawamura, 2006). \u067e\u0698\u0648\u0647\u0634 \u062f\u0627\u0644\u0628\u0686 \u0648 \u0647\u0645\u06a9\u0627\u0631\u0627\u0646 (\u06f2\u06f0\u06f1\u06f1) \u0646\u0634\u0627\u0646 \u062f\u0627\u062f \u06a9\u0647 \u0627\u0645\u06a9\u0627\u0646 \u0627\u0641\u0632\u0627\u06cc\u0634 \u063a\u0644\u0638\u062a \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u0633\u0631\u0645 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648 \u0647\u0641\u062a\u0647 \u0627\u0628\u062a\u062f\u0627\u06cc\u06cc \u067e\u0633 \u0627\u0632 \u0632\u0627\u06cc\u0634 \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0645\u0635\u0631\u0641 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u0645\u062d\u0627\u0641\u0638\u062a \u0634\u062f\u0647 \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 \u0634\u06a9\u0645\u0628\u0647 \u0648\u062c\u0648\u062f \u062f\u0627\u0631\u062f. \u0627\u06cc\u0646 \u0627\u0645\u0631 \u0628\u0631\u0627\u06cc \u062d\u06cc\u0648\u0627\u0646 \u0628\u0633\u06cc\u0627\u0631 \u0645\u0647\u0645 \u0627\u0633\u062a\u060c \u0646\u0647 \u0641\u0642\u0637 \u0628\u0647 \u062f\u0644\u06cc\u0644 \u0646\u0642\u0634 \u06a9\u0644\u06cc\u062f\u06cc \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0633\u0646\u062a\u0632 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0634\u06cc\u0631 \u0628\u0644\u06a9\u0647 \u0628\u0631\u0627\u06cc \u0633\u0646\u062a\u0632 VLDL \u062f\u0631 \u06a9\u0628\u062f\u060c \u062a\u0648\u0644\u06cc\u062f \u06af\u0644\u0648\u062a\u0627\u062a\u06cc\u0648\u0646 \u0648 \u062a\u0627\u0626\u0648\u0631\u06cc\u0646 (\u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646 \u0647\u0627\u06cc \u062f\u0631\u0648\u0646 \u0633\u0644\u0648\u0644\u06cc) \u0648 \u0647\u0645\u0686\u0646\u06cc\u0646 \u062a\u0627\u0645\u06cc\u0646 \u06af\u0631\u0648\u0647 \u0647\u0627\u06cc \u0645\u062a\u06cc\u0644 \u062f\u0627\u0631\u0627\u06cc \u0627\u0647\u0645\u06cc\u062a \u0627\u0633\u062a (Finkelstein, 1990). \u062f\u0631 \u063a\u06cc\u0631 \u0646\u0634\u062e\u0648\u0627\u0631\u06a9\u0646\u0646\u062f\u06af\u0627\u0646 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0646\u06a9\u062a\u0647 \u0645\u0647\u0645 \u062b\u0627\u0628\u062a \u0634\u062f\u0647 \u06a9\u0647 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u06a9\u0628\u062f \u06cc\u0627 \u0628\u0647 \u0639\u0628\u0627\u0631\u062a \u062f\u06cc\u06af\u0631 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0631\u0627\u0647 \u0628\u0631\u0627\u06cc \u062a\u0646\u0638\u06cc\u0645 \u0628\u06cc\u0627\u0646 \u0698\u0646\u060c \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u060c \u0648 \u067e\u0631\u062f\u0627\u0632\u0634 RNA \u0634\u0646\u0627\u062e\u062a\u0647 \u0645\u06cc \u0634\u0648\u062f.
\n\u06af\u0627\u0648\u0647\u0627 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 \u062f\u0686\u0627\u0631 \u0646\u0642\u0635 \u0633\u06cc\u0633\u062a\u0645 \u0627\u06cc\u0645\u0646\u06cc \u0645\u06cc \u0634\u0648\u0646\u062f \u06a9\u0647 \u06af\u0627\u0648 \u0631\u0627 \u0645\u0633\u062a\u0639\u062f \u0627\u0628\u062a\u0644\u0627 \u0628\u0647 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0627 \u0645\u06cc \u06a9\u0646\u062f (Goff, 2006). \u0627\u06af\u0631 \u06af\u0627\u0648 \u0627\u0632 \u06cc\u06a9 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0645\u0627\u0646\u0646\u062f \u0648\u0631\u0645 \u067e\u0633\u062a\u0627\u0646 \u06cc\u0627 \u0639\u0641\u0648\u0646\u062a \u0631\u062d\u0645 \u0631\u0646\u062c \u0628\u0628\u0631\u062f \u0633\u06cc\u0633\u062a\u0645 \u0627\u06cc\u0645\u0646\u06cc \u0628\u0627 \u0627\u0644\u062a\u0647\u0627\u0628\u060c \u0627\u0641\u0632\u0627\u06cc\u0634 \u062d\u0631\u0627\u0631\u062a \u0628\u062f\u0646\u060c \u0627\u0641\u0632\u0627\u06cc\u0634 \u062a\u0646\u0641\u0633 \u06cc\u0627 \u0636\u0631\u0628\u0627\u0646 \u0642\u0644\u0628 \u0639\u06a9\u0633 \u0627\u0644\u0639\u0645\u0644 \u0646\u0634\u0627\u0646 \u0645\u06cc \u062f\u0647\u062f. \u062a\u062d\u062a \u0634\u0631\u0627\u06cc\u0637 \u067e\u0631 \u0627\u0633\u062a\u0631\u0633\u060c \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u062a \u0647\u0627\u06cc \u0627\u06a9\u0633\u06cc\u0698\u0646 \u0641\u0639\u0627\u0644 (ROM) \u0645\u062d\u0635\u0648\u0644 \u0646\u0647\u0627\u06cc\u06cc \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u0633\u0645 \u0647\u0633\u062a\u0646\u062f. \u063a\u0644\u0638\u062a \u0628\u0627\u0644\u0627\u06cc ROM \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0628\u0631\u0627\u06cc \u0633\u0644\u0648\u0644 \u0647\u0627 \u0633\u0645\u06cc \u0628\u0627\u0634\u062f. \u0686\u0631\u0628\u06cc \u0647\u0627\u06cc \u067e\u0631\u0627\u06a9\u0633\u06cc\u062f \u0628\u0627 \u0627\u0644\u062a\u0647\u0627\u0628 \u0633\u06cc\u0633\u062a\u0645\u06cc\u06a9 \u0645\u0631\u062a\u0628\u0637 \u0647\u0633\u062a\u0646\u062f. \u062f\u0631 \u0632\u0645\u0627\u0646 \u062d\u0636\u0648\u0631 \u0627\u06cc\u0646 \u067e\u0631\u0627\u06a9\u0633\u06cc\u062f\u0647\u0627\u060c \u0686\u0631\u0628\u06cc \u0647\u0627\u06cc \u062f\u0631\u0648\u0646 \u0633\u0644\u0648\u0644\u06cc \u0628\u0627 \u0622\u0646\u0647\u0627 \u0648\u0627\u06a9\u0646\u0634 \u0645\u06cc \u062f\u0647\u0646\u062f \u06a9\u0647 \u0645\u0646\u062c\u0631 \u0628\u0647 \u0627\u0644\u062a\u0647\u0627\u0628 \u0645\u06cc \u0634\u0648\u062f (Bradford, 2012). \u06cc\u06a9\u06cc \u0627\u0632 \u0631\u0627\u06cc\u062c \u062a\u0631\u06cc\u0646 \u062a\u0627\u062b\u06cc\u0631\u0627\u062a \u0645\u0648\u0627\u062f \u0645\u063a\u0630\u06cc \u062f\u0631 \u0633\u0644\u0627\u0645\u062a \u062d\u06cc\u0648\u0627\u0646 \u0646\u0627\u0634\u06cc \u0627\u0632 \u0646\u0642\u0634 \u0622\u0646 \u0647\u0627 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646 \u0627\u0633\u062a (Waldron, 2014). \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u06cc\u0627 \u067e\u0627\u06cc\u06cc\u0646 \u0628\u0648\u062f\u0646 \u0633\u0637\u062d \u0645\u062d\u0641\u0627\u0638\u062a \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646\u06cc \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0645\u0646\u062c\u0631 \u0628\u0647 \u0622\u0633\u06cc\u0628 \u0647\u0627\u06cc \u0634\u062f\u06cc\u062f \u0628\u0627\u0641\u062a\u06cc \u06af\u0631\u062f\u062f (Zhao and Lacasse, 2008).
\n\u0647\u0645\u0632\u0645\u0627\u0646 \u0628\u0627 \u0622\u063a\u0627\u0632 \u0634\u06cc\u0631\u062f\u0647\u06cc \u0645\u0642\u062f\u0627\u0631 ROM \u0628\u0634\u062f\u062a \u0627\u0641\u0632\u0627\u06cc\u0634 \u0645\u06cc \u06cc\u0627\u0628\u062f\u060c \u062d\u062f\u0627\u0642\u0644 \u0628\u062e\u0634\u06cc \u0628\u0647 \u062f\u0644\u06cc\u0644 \u062f\u0648\u0628\u0631\u0627\u0628\u0631 \u0634\u062f\u0646 \u0645\u06cc\u0632\u0627\u0646 \u0633\u0648\u062e\u062a \u0648 \u0633\u0627\u0632 \u062f\u0631 \u06a9\u0628\u062f. ROM \u0647\u0627 \u0645\u0648\u0644\u06a9\u0648\u0644 \u0647\u0627\u06cc \u062d\u0627\u0648\u06cc \u0627\u06a9\u0633\u06cc\u0698\u0646\u06cc \u0647\u0633\u062a\u0646\u062f \u06a9\u0647 \u0627\u0632 \u0646\u0638\u0631 \u0634\u06cc\u0645\u06cc\u0627\u06cc\u06cc \u0622\u0645\u0627\u062f\u0647 \u0627\u0646\u062c\u0627\u0645 \u0648\u0627\u06a9\u0646\u0634 \u0645\u06cc \u0628\u0627\u0634\u0646\u062f. \u0627\u06cc\u0646 \u0645\u0648\u0644\u06a9\u0648\u0644 \u0647\u0627 \u0646\u062a\u06cc\u062c\u0647 \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u0633\u0645 \u0639\u0627\u062f\u06cc \u0627\u06a9\u0633\u06cc\u0698\u0646 \u0648 \u0633\u0644\u0648\u0644 \u0647\u0627\u06cc \u062f\u0641\u0627\u0639 \u06a9\u0646\u0646\u062f\u0647 \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 \u0622\u0633\u06cc\u0628 ROM \u0628\u0627 \u0622\u0646\u0632\u06cc\u0645 \u0647\u0627\u06cc\u06cc \u0647\u0633\u062a\u0646\u062f \u06a9\u0647 \u0628\u0647 \u0646\u0627\u0645 \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646 \u0634\u0646\u0627\u062e\u062a\u0647 \u0645\u06cc \u0634\u0648\u0646\u062f. \u0627\u0641\u0632\u0627\u06cc\u0634 ROM \u0646\u062a\u06cc\u062c\u0647 \u0627\u0644\u062a\u0647\u0627\u0628 \u0633\u06cc\u0633\u062a\u0645\u06cc\u06a9 \u0627\u0633\u062a. \u06a9\u0627\u0647\u0634 \u0627\u0633\u062a\u0631\u0633 \u0627\u06a9\u0633\u06cc\u062f\u0627\u062a\u06cc\u0648 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0628\u0631\u0627\u06cc \u06af\u0627\u0648 \u0645\u0641\u06cc\u062f \u0628\u0627\u0634\u062f. \u0627\u06af\u0631ROM \u0628\u06cc\u0634 \u0627\u0632 \u062d\u062f \u062a\u0648\u0644\u06cc\u062f \u0634\u0648\u062f \u0648 \u0622\u0646\u0632\u06cc\u0645 \u0647\u0627\u06cc \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646\u06cc \u0633\u0644\u0648\u0644\u06cc \u0628\u0631\u0627\u06cc \u062e\u0646\u062b\u06cc \u06a9\u0631\u062f\u0646 \u0622\u0646 \u062f\u0631 \u06a9\u0648\u062a\u0627\u0647 \u0645\u062f\u062a \u0646\u0627\u062a\u0648\u0627\u0646 \u0628\u0627\u0634\u0646\u062f\u060c ROM \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0622\u0633\u06cc\u0628 \u0633\u0644\u0648\u0644\u06cc \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647\u06cc \u0648\u0627\u0631\u062f \u06a9\u0646\u062f. \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646 \u0647\u0627 \u0645\u06cc \u062a\u0648\u0627\u0646\u0646\u062f \u0628\u0631\u0627\u06cc \u06a9\u0646\u062a\u0631\u0644 ROM \u0628\u0647 \u06af\u0627\u0648 \u06a9\u0645\u06a9 \u06a9\u0646\u0646\u062f\u060c \u0648\u06cc\u062a\u0627\u0645\u06cc\u0646 A \u0648 E \u0648 \u0633\u0644\u0646\u06cc\u0648\u0645 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646 \u0634\u0646\u0627\u062e\u062a\u0647 \u0634\u062f\u0647 \u0627\u0646\u062f \u0648 \u062a\u0627\u062b\u06cc\u0631 \u0622\u0646 \u0647\u0627 \u0628\u0631 \u0633\u0644\u0627\u0645\u062a \u06af\u0627\u0648 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 \u0628\u0647 \u062e\u0648\u0628\u06cc \u0634\u0646\u0627\u062e\u062a\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a (Sordillo et al., 2009). \u062c\u0644\u0648\u06af\u06cc\u0631\u06cc \u0627\u0632 \u0627\u0646\u0628\u0627\u0634\u062a ROM \u0648 \u0647\u0645\u0686\u0646\u06cc\u0646 \u0641\u0631\u0627\u0647\u0645 \u06a9\u0631\u062f\u0646 \u0633\u0648\u0628\u0633\u062a\u0631\u0627\u0647\u0627 \u0628\u0631\u0627\u06cc \u0622\u0646\u0632\u06cc\u0645 \u0647\u0627\u06cc \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646\u06cc \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0628\u0631\u0627\u06cc \u06cc\u06a9 \u062f\u0648\u0631\u0647 \u0634\u06cc\u0631\u062f\u0647\u06cc \u0633\u0627\u0644\u0645 \u062a\u0631 \u0648 \u0639\u0645\u0644\u06a9\u0631\u062f \u06a9\u0644\u06cc \u0628\u0647\u062a\u0631 \u0628\u0647 \u06af\u0627\u0648 \u06a9\u0645\u06a9 \u06a9\u0646\u062f. \u0645\u062f\u0644 \u0632\u06cc\u0631 \u0628\u0631\u0627\u06cc \u062a\u0648\u0635\u06cc\u0641 \u0631\u0648\u0627\u0628\u0637 \u0645\u062a\u0642\u0627\u0628\u0644 \u0628\u06cc\u0646 \u0627\u0644\u062a\u0647\u0627\u0628 \u0648 \u0627\u0633\u062a\u0631\u0633 \u0627\u06a9\u0633\u06cc\u062f\u0627\u062a\u06cc\u0648 \u0627\u0631\u0627\u0626\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a (\u0634\u06a9\u0644 \u06f2).
\n\u0634\u06a9\u0644 \u06f2: \u0645\u062f\u0644 \u0641\u0639\u0644\u06cc \u0639\u0644\u0644 \u0627\u062d\u062a\u0645\u0627\u0644\u06cc \u0622\u0633\u06cc\u0628 \u0628\u0627\u0641\u062a\u06cc (\u06a9\u0628\u062f\u060c \u0627\u067e\u06cc\u062a\u0644\u06cc\u0648\u0645 \u0634\u06a9\u0645\u0628\u0647\u060c \u063a\u062f\u062f \u067e\u0633\u062a\u0627\u0646\u06cc\u060c \u0627\u0646\u062f\u0627\u0645 \u062a\u0648\u0644\u06cc\u062f \u0645\u062b\u0644\u06cc) \u0648 \u067e\u0627\u0633\u062e \u0627\u0644\u062a\u0647\u0627\u0628\u06cc \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 \u0647\u0645\u0631\u0627\u0647 \u06cc\u0627 \u0628\u062f\u0648\u0646 \u0628\u0631\u0648\u0632 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0627\u06cc \u0639\u0641\u0648\u0646\u06cc \u0631\u0627 \u0628\u0647 \u062a\u0635\u0648\u06cc\u0631 \u0645\u06cc \u06a9\u0634\u062f (Bertoni and Trevisi,2013).<\/p>\n

\u0641\u0631\u0627\u06cc\u0646\u062f\u0647\u0627\u06cc \u0627\u0644\u062a\u0647\u0627\u0628\u06cc \u062a\u0648\u0633\u0637 \u06cc\u06a9 \u0639\u0627\u0645\u0644 \u0639\u0641\u0648\u0646\u06cc\u060c \u0627\u0633\u062a\u0631\u0633 \u0627\u06a9\u0633\u06cc\u062f\u0627\u062a\u06cc\u0648\u060c \u06cc\u0627 \u0639\u0645\u0644 \u062a\u0631\u06a9\u06cc\u0628\u06cc \u0645\u0633\u062a\u0642\u06cc\u0645 \u0628\u0631 \u06a9\u0628\u062f \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0633\u0627\u06cc\u062a\u0648\u06a9\u06cc\u0646 \u0647\u0627\u06cc \u067e\u06cc\u0634 \u0627\u0644\u062a\u0647\u0627\u0628\u06cc \u0634\u0627\u0645\u0644 IL-6\u060c TNF\u03b1\u060c \u0648 IL-1 \u0631\u062e \u0645\u06cc \u062f\u0647\u0646\u062f. \u06a9\u0628\u062f (\u0633\u0644\u0648\u0644 \u0647\u0627\u06cc \u06a9\u0628\u062f\u06cc) \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0647\u0627\u06cc \u062f\u0631\u0648\u0646 \u0633\u0644\u0648\u0644\u06cc (\u06af\u06cc\u0631\u0646\u062f\u0647) \u062f\u0627\u0631\u062f \u06a9\u0647 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0633\u0627\u06cc\u062a\u0648\u06a9\u06cc\u0646 \u0647\u0627 \u0631\u0627 \u062a\u0634\u062e\u06cc\u0635 \u062f\u0647\u062f\u060c \u062f\u0631 \u062d\u0627\u0644\u06cc\u06a9\u0647 \u0628\u0627 \u0627\u062a\u0635\u0627\u0644 \u0628\u0647 \u0627\u06cc\u0646 \u06af\u06cc\u0631\u0646\u062f\u0647 \u0647\u0627 \u0641\u0627\u06a9\u062a\u0648\u0631 \u0645\u063a\u0632\u06cc \u06a9\u0627\u067e\u0627-\u0628\u062a\u0627 (NFKB) \u0628\u0647 \u0648\u0633\u06cc\u0644\u0647 \u062a\u063a\u06cc\u06cc\u0631 \u0628\u06cc\u0627\u0646 \u0698\u0646 (mRNA) \u067e\u0627\u0633\u062e \u0645\u06cc \u062f\u0647\u062f \u0648 \u0645\u062a\u0639\u0627\u0642\u0628\u0627 \u0633\u0646\u062a\u0632 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0627\u0632 \u06cc\u06a9 \u06af\u0631\u0648\u0647 \u0627\u0646\u062a\u062e\u0627\u0628\u06cc \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0647\u0627 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0641\u0627\u0632 \u062d\u0627\u062f (APP) \u062f\u0633\u062a\u0647 \u0628\u0646\u062f\u06cc \u0634\u062f\u0647 \u0627\u0633\u062a. APP \u0645\u062b\u0628\u062a \u062a\u0648\u0633\u0637 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0641\u0632\u0627\u06cc\u0634 \u06cc\u0627\u0641\u062a\u0647 \u062f\u0631 \u062d\u0627\u0644\u06cc\u06a9\u0647 APP \u0645\u0646\u0641\u06cc \u06a9\u0627\u0647\u0634 \u06cc\u0627\u0641\u062a\u0647 \u0627\u0633\u062a (\u0634\u06a9\u0644 \u06f2). \u0628\u0646\u0627\u0628\u0631\u0627\u06cc\u0646\u060c \u0628\u0627 \u067e\u06cc\u0631\u0648\u06cc \u0627\u0632 \u062a\u063a\u06cc\u06cc\u0631 \u0645\u0648\u0642\u062a\u06cc \u062f\u0631 \u063a\u0644\u0638\u062a \u0647\u0627\u06cc \u0622\u0646 \u0647\u0627\u060c \u0645\u0627 \u0645\u06cc \u062a\u0648\u0627\u0646\u06cc\u0645 \u0631\u0627\u0628\u0637\u0647 \u0648\u0636\u0639\u06cc\u062a \u0627\u0644\u062a\u0647\u0627\u0628\u06cc \u06af\u0627\u0648\u0647\u0627 \u0631\u0627 \u062f\u0631 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u06a9\u0646\u06cc\u0645.
\n\u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u0645\u0646\u0628\u0639 \u062a\u062b\u0628\u06cc\u062a \u0634\u062f\u0647 \u062f\u06cc\u06af\u0631\u06cc \u0627\u0632 \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646 \u0647\u0627\u06cc \u06af\u0644\u0648\u062a\u0627\u062a\u06cc\u0648\u0646 \u0648 \u062a\u0627\u0626\u0648\u0631\u06cc\u0646 \u0627\u0633\u062a (Atmaca, 2004) \u0648 \u062e\u0648\u0627\u0635 \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646\u06cc \u0622\u0646 \u062f\u0631 \u06af\u0648\u0646\u0647 \u0647\u0627\u06cc \u062f\u06cc\u06af\u0631 \u0645\u0634\u0627\u0647\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a (Geumsoo et al., 2014). \u06cc\u06a9\u06cc \u0627\u0632 \u0622\u0646\u0632\u06cc\u0645 \u0647\u0627\u06cc \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646\u06cc \u06a9\u0644\u06cc\u062f\u06cc \u062f\u0631 \u0628\u0627\u0641\u062a \u0647\u0627\u060c \u0628\u0647 \u062e\u0635\u0648\u0635 \u062f\u0631 \u06a9\u0628\u062f\u060c \u06af\u0644\u0648\u062a\u0627\u062a\u06cc\u0648\u0646 \u067e\u0631\u0627\u06a9\u0633\u06cc\u062f\u0627\u0632 \u0627\u0633\u062a. \u0627\u06cc\u0646 \u0622\u0646\u0632\u06cc\u0645 \u062f\u0631 \u0628\u062e\u0634 \u0647\u0627\u06cc\u06cc \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0627\u0632 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u0645\u0634\u062a\u0642 \u0634\u0648\u062f (\u0634\u06a9\u0644 \u06f3). \u062c\u0644\u0648\u06af\u06cc\u0631\u06cc \u0627\u0632 \u0627\u0646\u0628\u0627\u0634\u062a ROS \u0648 \u0647\u0645\u0686\u0646\u06cc\u0646 \u0641\u0631\u0627\u0647\u0645 \u06a9\u0631\u062f\u0646 \u0633\u0648\u0628\u0633\u062a\u0631\u0627\u0647\u0627 \u0628\u0631\u0627\u06cc \u0622\u0646\u0632\u06cc\u0645 \u0647\u0627\u06cc \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646\u06cc \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0628\u0647 \u06af\u0627\u0648 \u062f\u0631 \u062c\u0647\u062a \u062f\u0627\u0634\u062a\u0646 \u062f\u0648\u0631\u0647 \u0634\u06cc\u0631\u062f\u0647\u06cc \u0633\u0627\u0644\u0645 \u062a\u0631 \u0648 \u0639\u0645\u0644\u06a9\u0631\u062f \u06a9\u0644\u06cc \u0628\u0647\u062a\u0631 \u06a9\u0645\u06a9 \u06a9\u0646\u062f.
\n\u0634\u06a9\u0644 \u06f3: \u0646\u0642\u0634 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u0633\u0645 \u0628\u062f\u0646 \u06af\u0627\u0648<\/p>\n

\u0646\u062a\u0627\u06cc\u062c \u0628\u062f\u0633\u062a \u0622\u0645\u062f\u0647 \u0627\u0632 \u06cc\u06a9 \u067e\u0698\u0648\u0647\u0634 \u062a\u0627\u062b\u06cc\u0631 \u062a\u063a\u0630\u06cc\u0647 \u06cc\u06a9 \u062c\u06cc\u0631\u0647 \u063a\u0646\u06cc \u0627\u0632 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u0628\u0631 \u0627\u0633\u062a\u0631\u0633 \u0627\u06a9\u0633\u06cc\u062f\u0627\u062a\u06cc\u0648 \u0648 \u0648\u0636\u0639\u06cc\u062a \u0627\u06cc\u0645\u0646\u06cc \u06af\u0627\u0648\u0647\u0627 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0627\u0633\u062a (Osorio et al., 2013, 2014). \u0633\u0647 \u06af\u0631\u0648\u0647 \u0627\u0632 \u06af\u0627\u0648\u0647\u0627 \u0628\u0627 \u06cc\u06a9 \u062c\u06cc\u0631\u0647 \u067e\u0627\u06cc\u0647 \u0627\u0632 \u06f2\u06f1 \u0631\u0648\u0632 \u067e\u06cc\u0634 \u0627\u0632 \u0632\u0627\u06cc\u0634 \u062a\u0627 \u06f2\u06f8 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u0632\u0627\u06cc\u0634 \u062a\u063a\u0630\u06cc\u0647 \u0634\u062f\u0646\u062f. \u06cc\u06a9 \u06af\u0631\u0648\u0647 \u0627\u0632 \u06af\u0627\u0648\u0647\u0627 \u062c\u06cc\u0631\u0647 \u0627\u06cc \u0628\u0627 \u06a9\u0645\u0628\u0648\u062f \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631\u06cc\u0627\u0641\u062a \u06a9\u0631\u062f\u0646\u062f. \u062f\u0648 \u06af\u0631\u0648\u0647 \u062f\u06cc\u06af\u0631 \u0628\u0627 \u0647\u0645\u0627\u0646 \u062c\u06cc\u0631\u0647 \u067e\u0627\u06cc\u0647 \u0648\u0644\u06cc \u063a\u0646\u06cc \u0634\u062f\u0647 \u0628\u0627 \u06cc\u06a9 \u06cc\u0627 \u062f\u0648 \u0645\u0646\u0628\u0639 \u062a\u062c\u0627\u0631\u06cc \u0627\u0632 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u0628\u0631\u0627\u06cc \u062f\u0633\u062a\u06cc\u0627\u0628\u06cc \u0628\u0647 \u0646\u0633\u0628\u062a \u06f2\u066b\u06f8:\u06f1 \u0644\u0627\u06cc\u0632\u06cc\u0646 \u0628\u0647 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062a\u063a\u0630\u06cc\u0647 \u0634\u062f\u0646\u062f. \u06af\u0627\u0648\u0647\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0634\u062f\u0647 \u0628\u0627 \u062c\u06cc\u0631\u0647 \u063a\u0646\u06cc \u0634\u062f\u0647 \u0628\u0627 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u0628\u0637\u0648\u0631 \u0645\u06cc\u0627\u0646\u06af\u06cc\u0646 \u06f4\u066b\u06f7 \u067e\u0648\u0646\u062f (\u06f2\u066b\u06f1\u06f3 \u06a9\u06cc\u0644\u0648\u06af\u0631\u0645) \u062e\u0648\u0631\u0627\u06a9 \u0628\u06cc\u0634\u062a\u0631\u06cc \u062f\u0631 \u0647\u0631 \u0631\u0648\u0632 \u0645\u0635\u0631\u0641 \u06a9\u0631\u062f\u0646\u062f \u0648 \u0634\u06cc\u0631 \u062a\u0648\u0644\u06cc\u062f\u06cc \u0627\u0635\u0644\u0627\u062d \u0634\u062f\u0647 \u0628\u0631 \u0627\u0633\u0627\u0633 \u0627\u0646\u0631\u0698\u06cc (ECM) \u0622\u0646 \u0647\u0627 \u0628\u0647 \u0645\u06cc\u0632\u0627\u0646 \u06f8\u066b\u06f6 \u067e\u0648\u0646\u062f (\u06f3\u066b\u06f9 \u06a9\u06cc\u0644\u0648\u06af\u0631\u0645) \u062f\u0631 \u0631\u0648\u0632 \u062f\u0631 \u0637\u0648\u0644 \u06f2\u06f8 \u0631\u0648\u0632 \u0627\u0628\u062a\u062f\u0627\u06cc\u06cc \u062f\u0648\u0631\u0647 \u0634\u06cc\u0631\u062f\u0647\u06cc \u0627\u0641\u0632\u0627\u06cc\u0634 \u06cc\u0627\u0641\u062a (\u062c\u062f\u0648\u0644 \u06f1).
\n\u062c\u062f\u0648\u0644 \u06f1: \u0645\u0627\u062f\u0647 \u062e\u0634\u06a9 \u0645\u0635\u0631\u0641\u06cc\u060c \u0634\u06cc\u0631\u060c \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u060c \u0686\u0631\u0628\u06cc \u062a\u0648\u0644\u06cc\u062f\u06cc \u0648 \u0627\u0632 \u06af\u0627\u0648 \u0647\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0634\u062f\u0647 \u0628\u0627 \u06cc\u06a9 \u062c\u06cc\u0631\u0647 \u06a9\u0646\u062a\u0631\u0644 \u0648 \u062c\u06cc\u0631\u0647 \u0647\u0627\u06cc \u063a\u0646\u06cc \u0634\u062f\u0647 \u0628\u0627 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 (\u0645\u062a\u0627 \u0627\u0633\u0645\u0627\u0631\u062a \u0648 \u0627\u0633\u0645\u0627\u0631\u062a\u0627\u0645\u06cc\u0646) (Osorio et al., 2013).
\n\u062c\u06cc\u0631\u0647 \u0633\u0637\u062d \u0645\u0639\u0646\u06cc \u062f\u0627\u0631\u06cc \u0622\u0645\u0627\u0631\u06cc
\n\u067e\u0627\u0631\u0627\u0645\u062a\u0631 \u06a9\u0646\u062a\u0631\u0644 \u0645\u062a\u0627 \u0627\u0633\u0645\u0627\u0631\u062a \u0627\u0633\u0645\u0627\u0631\u062a\u0627\u0645\u06cc\u0646 \u062c\u06cc\u0631\u0647 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646
\n\u0645\u0627\u062f\u0647 \u062e\u0634\u06a9 \u0645\u0635\u0631\u0641\u06cc \u06f2\u06f9\u066b\u06f3 \u06f3\u06f3\u066b\u06f5 \u06f3\u06f4\u066b\u06f4 \u06f0\u066b\u06f1\u06f8 \u06f0\u066b\u06f0\u06f6
\n\u0634\u06cc\u0631 \u062a\u0648\u0644\u06cc\u062f\u06cc (Kg\/d) 35.65 38.06 39.96 0.15 0.08
\n\u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0634\u06cc\u0631 (%) \u06f3\u066b\u06f0\u06f4 \u06f3\u066b\u06f2\u06f6 \u06f3\u066b\u06f1\u06f9 \u06f0\u066b\u06f1\u06f3 \u06f0\u066b\u06f0\u06f5
\n\u0686\u0631\u0628\u06cc \u0634\u06cc\u0631 (%) \u06f4\u066b\u06f2\u06f7 \u06f4\u066b\u06f6\u06f8 \u06f4\u066b\u06f0\u06f9 \u06f0\u066b\u06f5\u06f9 \u06f0\u066b\u06f3\u06f6
\n\u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0634\u06cc\u0631 \u062a\u0648\u0644\u06cc\u062f\u06cc (Kg\/d) 1.11 1.23 1.24 0.08 0.03
\n\u0686\u0631\u0628\u06cc \u0634\u06cc\u0631 \u062a\u0648\u0644\u06cc\u062f\u06cc (Kg\/d) 1.64 1.84 1.8 0.11 0.04
\n\u0634\u06cc\u0631 \u062a\u0648\u0644\u06cc\u062f\u06cc \u0627\u0635\u0644\u0627\u062d \u0634\u062f\u0647 \u0628\u0631 \u0627\u0633\u0627\u0633 \u0627\u0646\u0631\u0698\u06cc (Kg\/d) 40.95 44.72 44.95 0.09 0.03<\/p>\n

\u0647\u0645\u0686\u0646\u06cc\u0646 \u06af\u0627\u0648\u0647\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0634\u062f\u0647 \u0628\u0627 \u062c\u06cc\u0631\u0647 \u0647\u0627\u06cc \u063a\u0646\u06cc \u0634\u062f\u0647 \u0628\u0627 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u063a\u0644\u0638\u062a \u0628\u0627\u0644\u0627\u062a\u0631\u06cc \u0627\u0632 \u06a9\u0627\u0631\u0646\u06cc\u062a\u06cc\u0646 \u0636\u0631\u0648\u0631\u06cc \u0628\u0631\u0627\u06cc \u0627\u0646\u062a\u0642\u0627\u0644 NEFA \u0627\u0632 \u0633\u06cc\u062a\u0648\u0632\u0648\u0644 \u0628\u0647 \u062f\u0627\u062e\u0644 \u0645\u06cc\u062a\u0648\u06a9\u0646\u062f\u0631\u06cc \u0628\u0631\u0627\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0633\u06cc\u0648\u0646 \u0627\u0633\u06cc\u062f\u0647\u0627\u06cc \u0686\u0631\u0628 \u062f\u0627\u0634\u062a\u0646\u062f (Drackley, 1999)\u060c \u0648 \u062a\u0645\u0627\u06cc\u0644 \u0628\u0647 \u063a\u0644\u0638\u062a \u067e\u0627\u06cc\u06cc\u0646 \u062a\u0631 \u0641\u0633\u0641\u0627\u062a\u06cc\u062f\u06cc\u0644 \u06a9\u0648\u0644\u06cc\u0646 \u062f\u0627\u0631\u0627\u06cc \u0627\u0647\u0645\u06cc\u062a \u062f\u0631 \u0646\u0633\u0628\u062a \u062a\u062c\u0645\u0639 \u0628\u0647 \u062e\u0631\u0648\u062c \u0686\u0631\u0628\u06cc \u0647\u0627 \u0628\u0647 \u0628\u06cc\u0631\u0648\u0646 \u0627\u0632 \u06a9\u0628\u062f \u0628\u0647 \u0634\u06a9\u0644 VLDL (Osorio et al., 2014) \u062f\u0627\u0634\u062a\u0646\u062f. \u0639\u0644\u0627\u0648\u0647 \u0628\u0631 \u0627\u06cc\u0646 \u06af\u0627\u0648\u0647\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0634\u062f\u0647 \u0628\u0627 \u062c\u06cc\u0631\u0647 \u0647\u0627\u06cc \u063a\u0646\u06cc \u0634\u062f\u0647 \u0628\u0627 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u063a\u0644\u0638\u062a \u067e\u0627\u06cc\u06cc\u0646 \u062a\u0631\u06cc \u0627\u0632 \u0633\u0631\u0648\u0644\u0648\u067e\u0644\u0627\u0633\u0645\u06cc\u0646 \u0648 \u0622\u0645\u06cc\u0644\u0648\u0626\u06cc\u062f \u0633\u0631\u0645 A (\u0647\u0631 \u062f\u0648 APP \u0645\u062b\u0628\u062a) \u062f\u0631 \u062e\u0648\u0646 \u0648 \u06a9\u0627\u0647\u0634 \u067e\u0627\u0633\u062e \u0627\u0644\u062a\u0647\u0627\u0628\u06cc \u062f\u0627\u0634\u062a\u0646\u062f\u060c \u06af\u0627\u0648\u0647\u0627 \u0647\u0645\u0686\u0646\u06cc\u0646 \u0648\u0636\u0639\u06cc\u062a \u0622\u0646\u062a\u06cc \u0627\u06a9\u0633\u06cc\u062f\u0627\u0646\u06cc \u0628\u0647\u062a\u0631\u06cc \u062f\u0631 \u0627\u062b\u0631 \u0638\u0631\u0641\u06cc\u062a \u062c\u0630\u0628 \u0628\u0627\u0644\u0627\u062a\u0631 \u0631\u0627\u062f\u06cc\u06a9\u0627\u0644 \u0627\u06a9\u0633\u06cc\u0698\u0646 \u0648 \u063a\u0644\u0638\u062a \u06af\u0644\u0648\u062a\u0627\u062a\u06cc\u0648\u0646 \u062f\u0627\u0634\u062a\u0646\u062f (\u062c\u062f\u0648\u0644 \u06f2).
\n\u062c\u06cc\u0631\u0647 \u0633\u0637\u062d \u0645\u0639\u0646\u06cc \u062f\u0627\u0631\u06cc \u0622\u0645\u0627\u0631\u06cc
\n\u067e\u0627\u0631\u0627\u0645\u062a\u0631 \u06a9\u0646\u062a\u0631\u0644 \u0645\u062a\u0627 \u0627\u0633\u0645\u0627\u0631\u062a \u0627\u0633\u0645\u0627\u0631\u062a\u0627\u0645\u06cc\u0646 \u062c\u06cc\u0631\u0647 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646
\n\u06a9\u0627\u0631\u0646\u06cc\u062a\u06cc\u0646 mg\/L 37.5 98.2 66 0.01 <0.01
\n\u0641\u0633\u0641\u0627\u062a\u06cc\u062f\u06cc\u0644 \u06a9\u0648\u0644\u06cc\u0646 uM\/g \u0627\u0632 \u0628\u0627\u0641\u062a \u06f1\u06f0\u066b\u06f6 \u06f7\u066b\u06f7 \u06f9\u066b\u06f1 \u06f0\u066b\u06f1\u06f5 \u06f0\u066b\u06f0\u06f7
\n\u0633\u0631\u0648\u0644\u0648\u067e\u0644\u0627\u0633\u0645\u06cc\u0646 umol\/l 3.02 2.68 2.71 0.03 0.009
\n\u0622\u0645\u06cc\u0644\u0648\u0626\u06cc\u062f \u0633\u0631\u0645 A ug\/ml 61 40.7 43.5 0.17 0.06
\n\u0638\u0631\u0641\u06cc\u062a \u062c\u0630\u0628 \u0631\u0627\u062f\u06cc\u06a9\u0627\u0644 \u0627\u06a9\u0633\u06cc\u0698\u0646 mol\/L 11.9 12.9 12.4 0.05 0.04
\n\u06af\u0644\u0648\u062a\u0627\u062a\u06cc\u0648\u0646 mM 1.27 1.55 1.73 0.09 0.04<\/p>\n

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\n\u0645\u0646\u0627\u0628\u0639:
\nAtmaca, G. 2004. An? oxidant eff ects of sulfurcontaining amino acids. Yonsei medical journal 45:776-788.<\/p>\n

Bertoni, G. and E. Trevisi. 2013. Use of the liver activity index and other metabolic variables in the assessment of metabolic health in dairy herds. Vet. Clin. Food Anim 29: 414-431.<\/p>\n

Bradford, B. 2011. Inflammation and transition cow disorders. htt p:\/\/www.extension.org\/pages\/23301\/infl amma? on-and-transition-cow-disorders.<\/p>\n

Dalbach, K. F., M. Larsen, B. M. Raun, and N. B. Kristensen. 2011. Effects of supplementation with 2-hydroxy-4-(methylthio)-butanoic acid isopropyl ester on splanchnic amino acid metabolism and essential amino acid mobilization in postpartum transition Holstein cows. Journal of dairy science 94:3913-3927.<\/p>\n

Drackley, J.K. 1999. ADSA Foundation Scholar Award. Biology of dairy cows during the transition period: the final frontier? J. Dairy Sci. 82:2259-2273.<\/p>\n

Durand, D., Chilliard, Y. and Bauchart,D. 1992. Effects of Lysine and Methionine on in vivo hepatic secretion of VLDL in the high yielding dairy cow. J. Dairy Sci. 75 (Supplement 1).<\/p>\n

Finkelstein, J. D. 1990. Methionine metabolism in mammals. The Journal of nutritional biochemistry 1:228-237.<\/p>\n

Geumsoo, K., S. W. Weiss and R. L Levine. 2014. Methionine oxidation and reduction in proteins. Biochimica et Biophysica Acta. 1841:901-905.<\/p>\n

Goff , J.P. 2006. Major Advances in our understanding of nutritional influences on bovine health. J. Dairy Sci. 89:1291-1301.<\/p>\n

Grummer, R. R. 1993. Etiology of lipid-related metabolic disorders in periparturient dairy cows. Journal of dairy science 76:3882-3896.<\/p>\n

Kuhla, B., G. Nurnberg, D. Albrecht, S. Gors, H. M Hammon and C. C. Metges. 2011. J. of Proteome. Research. 10:4252-4262.<\/p>\n

McCarthy, R. D., G. A. Porter, and L. C. Griel. 1968. Bovine ketosis and depressed fat test in milk: a problem of methionine metabolism and serum lipoprotein aberra? on. Journal of dairy science 51:459-462.<\/p>\n

Osorio, J. S., P. Ji, J. K. Drackley, N. D. Luchini and J. J. Loor. 2013. Supplemental Smartamine M or MetaSmart during the transition period benefits postpartal cow performance and blood neutrophil function. J. Dairy Science 96:6248.<\/p>\n

Osorio, J. S., E. Trevisi, P. Ji, J. K. Drackley, D. Luchini, G. Bertoni, and J. J. Loor. 2014. Biomarkers of inflammation, metabolism, and oxidative stress in blood, liver, and milk reveal a better immunometabolic status in peripartal cows supplemented with Smartamine M or MetaSmart. (Submitted).<\/p>\n

Sordillo, L.M. and S.L. Aitken. 2009. Impact of oxidative stress on the helath and the immune function of dairy cattle. Vet. Immunol Immunopathol. 128(1-1):104-9.
\nVan der Drift , S.G.A., M. Houwegling, J.T. Schonewille, A.G. M. Tielens and R. Jorristma. 2012. Protein and fat mobilization and associations with serum B-hydroxybutyrate concentrations in dairy cows. J. Dairy Sci. 95:4911-4920.<\/p>\n

Waldron, M. R. 2014. Prescribed Feeding Prepartum for improved Health and Performance Postpartum. In: Proceedings of the Tri-State Dairy Nutrition Conference. 27-39.<\/p>\n

Zhao, X. and P. Lacasse. 2008. Mammary tissue damaga during bovine mastitis: Causes and control. J. Anim. Sci. 86:57-65.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u0645\u0632\u0627\u06cc\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644: The Benefits of Feeding Methionine during the Transition Phase: D. Luchini and J. Loor \u062a\u0631\u062c\u0645\u0647: \u0639\u0631\u0641\u0627\u0646 \u0631\u0633\u062a\u0645\u06cc \u062f\u0627\u0646\u0634\u062c\u0648\u06cc \u062f\u06a9\u062a\u0631\u06cc \u062a\u063a\u0630\u06cc\u0647 \u062f\u0627\u0645 \u06af\u0627\u0648\u0647\u0627\u06cc \u0634\u06cc\u0631\u06cc \u067e\u0633 \u0627\u0632 \u0632\u0627\u06cc\u0634 \u062f\u0631 \u0645\u0639\u0631\u0636 \u0628\u0627\u0644\u0627\u062a\u0631\u06cc\u0646 \u062e\u0637\u0631 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0633\u062a\u0646\u062f. \u0634\u06cc\u0648\u0639 \u0628\u0627\u0644\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0627 \u062f\u0631 \u0637\u0648\u0644 \u0627\u06cc\u0646 \u062f\u0648\u0631\u0647 \u0639\u0645\u0644\u06a9\u0631\u062f \u0622\u0646 \u0647\u0627 \u0631\u0627 \u062f\u0631 \u062f\u0648\u0631\u0627\u0646 \u0634\u06cc\u0631\u062f\u0647\u06cc \u0648 […]<\/p>\n","protected":false},"author":934,"featured_media":22641,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,12],"tags":[341,11702,11701,6897,11703,11700],"class_list":["post-23070","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-articles","tag-341","tag-11702","tag-11701","tag-6897","tag-11703","tag-11700"],"yoast_head":"\n\u0645\u0632\u0627\u06cc\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 - \u067e\u0627\u064a\u06af\u0627\u0647 \u0627\u0637\u0644\u0627\u0639 \u0631\u0633\u0627\u0646\u064a \u0643\u0634\u0627\u0648\u0631\u0632\u064a \u0648 \u0635\u0646\u0627\u06cc\u0639 \u063a\u0630\u0627\u06cc\u06cc \u0627\u064a\u0631\u0627\u0646<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/agna.ir\/?p=23070\" \/>\n<meta property=\"og:locale\" content=\"fa_IR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0645\u0632\u0627\u06cc\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644 - \u067e\u0627\u064a\u06af\u0627\u0647 \u0627\u0637\u0644\u0627\u0639 \u0631\u0633\u0627\u0646\u064a \u0643\u0634\u0627\u0648\u0631\u0632\u064a \u0648 \u0635\u0646\u0627\u06cc\u0639 \u063a\u0630\u0627\u06cc\u06cc \u0627\u064a\u0631\u0627\u0646\" \/>\n<meta property=\"og:description\" content=\"\u0645\u0632\u0627\u06cc\u0627\u06cc \u062a\u063a\u0630\u06cc\u0647 \u0645\u062a\u06cc\u0648\u0646\u06cc\u0646 \u062f\u0631 \u0637\u0648\u0644 \u062f\u0648\u0631\u0647 \u0627\u0646\u062a\u0642\u0627\u0644: The Benefits of Feeding Methionine during the Transition Phase: D. Luchini and J. Loor \u062a\u0631\u062c\u0645\u0647: \u0639\u0631\u0641\u0627\u0646 \u0631\u0633\u062a\u0645\u06cc \u062f\u0627\u0646\u0634\u062c\u0648\u06cc \u062f\u06a9\u062a\u0631\u06cc \u062a\u063a\u0630\u06cc\u0647 \u062f\u0627\u0645 \u06af\u0627\u0648\u0647\u0627\u06cc \u0634\u06cc\u0631\u06cc \u067e\u0633 \u0627\u0632 \u0632\u0627\u06cc\u0634 \u062f\u0631 \u0645\u0639\u0631\u0636 \u0628\u0627\u0644\u0627\u062a\u0631\u06cc\u0646 \u062e\u0637\u0631 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0633\u062a\u0646\u062f. \u0634\u06cc\u0648\u0639 \u0628\u0627\u0644\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0627 \u062f\u0631 \u0637\u0648\u0644 \u0627\u06cc\u0646 \u062f\u0648\u0631\u0647 \u0639\u0645\u0644\u06a9\u0631\u062f \u0622\u0646 \u0647\u0627 \u0631\u0627 \u062f\u0631 \u062f\u0648\u0631\u0627\u0646 \u0634\u06cc\u0631\u062f\u0647\u06cc \u0648 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/agna.ir\/?p=23070\" \/>\n<meta property=\"og:site_name\" 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during the Transition Phase: D. Luchini and J. 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